INNOTEST® β-AMYLOID(1-42)

The INNOTEST β-AMYLOID(1-42) is a solid-phase enzyme immunoassay for the quantitative determination of β-amyloid(1-42) in human cerebrospinal fluid (CSF).

The combined use of CSF-Tau and CSF-β-amyloid(1-42) marker concentrations allows differentiation between Alzheimer’s disease (AD) and normal aging or other neurological diseases such as depression.1-6

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    For research use only
    INNOTEST® β-AMYLOID(1-42)

    Product number 81583

    96 Tests
    Please contact your local Fujirebio representative for the availability of this product in your country.

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      Features & Benefits

      • User-friendly enzyme  immunoassay, standard technology
      • Generic and color-coded components
      • Easily automated on microplate processor (generic components)
      • Ready-to-use Calibrators reduce inter and intra run variation
      • Run Validation Controls for assay run validation
      • Sample volume: 25 µL CSF. Duplicate testing is strongly recommended and requires 2 x 25 µL CSF.
      • Calibrator range: 62,5 to 4000 pg/mL
      • This assay should be used in combination with the Aβ(1-42) CAL-RVC pack, article no. 81584.

       

      References

      1. Andreasen et al. Evaluation of CSF-tau and CSF- Aβ42 as diagnostic markers for Alzheimer’s disease in clinical practice. Arch Neurol 2001;58:373-379.
      2. Sunderland et al. Decreased b-amyloid1-42 and Increased Tau Levels in Cerebrospinal Fluid of Patients With Alzheimer disease. Journal of the American Medical Association 2003;289:2094-2103.
      3. Hansson et al. Association between CSF biomarkers and incipient Alzheimer’s disease in patients with mild cognitive impairment: a follow-up study. Lancet Neurol 2006; 5: 228-234
      4. Mattsson et al. CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment. JAMA 2009; 302(4): 385-393.
      5. Tabaraud et al. Alzheimer CSF biomarkers in routine clinical setting. Acta Neurol Scand. 2012; 125(6): 416-23.
      6. Buchhave et al. Cerebrospinal fluid levels of β-amyloid 1-42, but not of tau, are fully changed already 5 to 10 years before the onset of Alzheimer dementia. Arch Gen Psychiatry 2012; 69(1): 98-106.

      Additional useful information about Alzheimer’s disease can be found on the following websites: The Alzheimer forum site:

       

      Disclaimer

      A license regarding amyloid beta antibodies contained in this product under patents US 5750349 has been obtained from Takeda Pharmaceutical Company Limited. Furthermore, a license for the use of amyloid beta monoclonal antibodies contained in this product under patents US 6114133, US7811769, and EP 0792458 has been obtained from Eli Lilly and Company.

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