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Scientific Poster - Pre-analytics of the Aβ1-42/Aβ1-40 Ratio in Fresh and Frozen Samples Using an Optimized CSF Collection Protocol

Oct 14, 2022

Background

Cerebrospinal fluid (CSF) biomarkers β-amyloid1-42 (Aβ1-42) and β-amyloid1-40 (Aβ1-40)
have shown high concordance with amyloid PET when used as the ratio Aβ1-42/Aβ1-40 (amyloid ratio).
While Aβ1-42 differentiates individuals who have amyloid burden in the brain from those who do not
by decreasing in the CSF, Aβ1-40 remains constant and normalizes the measurement of amyloid on an
individual level to compensate for high and low amyloid producers. Normalization is also necessary to
compensate for amyloid loss due to the tendency of amyloid protein to aggregate and adsorb to
surfaces. In this study we examined the ability of Aβ1-42/Aβ1-40 to compensate for concentration loss
along a specified collection protocol. Additionally, the change in Aβ1-42/Aβ1-40 concentration was
analyzed under fresh and frozen conditions to determine the feasibility of a single cutoff between
sample conditions.

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