Lumipulse® G Pan-ApoE

Immunoassay to be used with the automated LUMIPULSE G System for the quantitative measurement of all isoforms of the apolipoprotein E among which ApoE2, ApoE3, ApoE4 (Pan-ApoE) in human plasma. This product is not for use in diagnostic procedures, for ‘Research Use Only’. This product is for professional use only.

Contact sales for information
For research use only
Lumipulse® G Pan-ApoE Immunoreaction Cartridges

Product number 81449

3 × 14 Tests
Lumipulse G Pan-ApoE Calibrators

Product number 81450

1 × 5 Concentrations
Please contact your local Fujirebio representative for the availability of this product in your country.

Click here to navigate

  • Contact sales for information
  • Details
  • Conditions of sale
  • Citations
  • Documentation
  • Insights
  • Product inquiry
  • Related products

  • Details

    Apolipoprotein E (ApoE) is a polymorphic glycoprotein which plays a role in the transport and metabolism of triglyceride-cholesterol and is known to be synthesized in the liver, brain and other organs. It is encoded by the APOE gene, which has three different alleles (ε2, ε3, ε4) that encode for three different ApoE protein isoforms (ApoE2, ApoE3, and ApoE4). A combination of these isoforms results in 6 phenotypes (3 homozygous types (E2/E2; E3/E3; E4/E4) and 3 heterozygous types (E2/E3; E3/E4; E2/E4)).1,2

    When used in conjunction with the Lumipulse G ApoE4 assay to determine the ApoE4/Pan-ApoE ratio, this ratio can be used to determine the ApoE proteotype status related to ApoE4, meaning absence (null) or presence of ApoE4 only (homozygous) or the combination with ApoE2 or E3 (heterozygous).

    The assay reflects the ApoE4 protein expression level rather than the genotype, as evidenced by the observation that liver-transplanted patients have the phenotype of the donor.3

     

     

    See the LUMIPULSE G1200 working in this video:

     

    References:

    1. Emi M, et al. Genotyping and sequence analysis of apolipoprotein E isoforms. Genomics, 3(4): 373–379, 1988.
    2. Utermann G, et al. Genetics of the apolipoprotein E-system in man. Am J Hum Genet, 32(3): 339-347, 1980.
    3. Linton M, et al. Phenotypes of apolipoprotein B and apolipoprotein E after liver transplantation. J Clin Invest, 88(1): 270–281, 1991.

  • Conditions of sale

    To read the end user conditions of sale for this product please visit our Resource center.

  • Citations

  • Insights

  • Product inquiry

    CAPTCHA

    The provision of your data implies your consent to the processing of your data in our database and, depending on the option you choose, to receiving our monthly newsletter by e-mail.

    For more information on how we process your personal data and regarding the rights you have in this respect, we refer to our privacy policy, which we hold at your disposal HERE.

    If you no longer wish to receive our newsletter, you have the option to unsubscribe via the ‘unsubscribe’ tool at the bottom of the newsletter. If you want to have your data removed from our database, please contact us at: privacy@fujirebio.com.

Veuillez confirmer que vous êtes un professionnel de la santé

Le contenu de ce site web est en partie réservé aux professionnels de santé qui sont directement impliqués dans la fourniture de services de soins de santé aux patients. Si vous êtes un professionnel de santé et que vous disposez de tous les droits d'accès, veuillez confirmer en cliquant sur le bouton 'oui'.

Choose your country or region

Once you have made this selection we will show you only the content that is relevant for your country. You can change this setting any time by clicking on the flag in the top toolbar of our website and choosing another country.
The content of this website is in part restricted to healthcare professionals who are directly involved in the provision of healthcare services to patients. If you are a health professional and you have full access rights, please check this box and confirm below.