CanAg^® CA242^™ EIA

The tumor marker CA242™ is defined by the monoclonal antibody C242™. The chemical structure of the antigenic determinant is not exactly known, but the determinant has been shown to be a sialylated carbohydrate structure. In serum, CA242™ is found on the same mucin complex as CA50 and sialylated Lewis A (CA19-9). Thus, CA242™ is related, but not identical to the epitope of CA19-9^{1, 2}. Serum levels of CA242 are low in healthy subjects and subjects with benign diseases, while elevated levels are commonly found in serum from patients with gastrointestinal cancer³. The CA242™ marker may be used as an aid in the diagnosis and management of patients with known or suspected gastrointestinal carcinomas^4-9. The CanAg Diagnostics CA242 EIA should not be used as a substitute for any established clinical examination of malignancy, but may be used as a complement to existing clinical and laborator methods.

References

1. Johansson, C., Nilsson, O., Baeckström, D., Jansson, E.-L. and Lindholm, L. (1991) Novel Epitopes on the CA50-Carrying Antigen: Chemical and Immu- nochemical Studies, Tumor Biol., 12, 159-179.

2. Johansson, C., Nilsson, O. and Lindholm, L., (1991) Comparison of Serological Expression of Different Epitopes on the CA50-Carrying Antigen CanAg, Int. J. Cancer, 48, 757-763.

3. Nilsson, O., Johansson, C., Glimelius, B., Persson B., Nørgaard-Pedersen, B., Andrén-Sandberg, Å., and Lindholm L. (1992): Sensitivity and specificity of CA242 in gastrointestinal cancer. A comparison with CEA, CA50 and CA19-9. Br J Cancer 65, 215-221.

4. Dahlén U., Karlsson B., Lindholm L., Nilsson O., (1993) Development of an enzyme immuno-assay for determination of the tumor associated antigen CA242, J. Tumor Marker Oncology 8, 3, p 111.

5. Kawa, S., Tokoo, M., Hasebe, O., Hayashi, K., Imai, H., Oguchi, H., Kiyosawa, K., Furuta, S., and Homma, T.,(1994) Comparative study of CA242 and CA19-9 for the diagnosis of pancreatic cancer, Br. J. Cancer, 70, 481-486.

6. Von Kleist, Hesse, Kananeeh, (1996) Comparative Evaluation of Four Tumor Markers, CA 242, CA 19-9, TPA, and CEA in Carcinomas of the Colon, Anti-cancer Research 16: 2325-2332.

7. Spila A, Ferroni P, Cosimelli M, D'Alessandro R, Abbolito MR, Mariotti S, Aloe S, Carone MD, Graziano F, Tedesco M, Martini F, Mancini R, Stigliano V, Roselli M, Guadagni F. (2001) Comparative analysis of CA 242 and CA 19-9 serum tumor markers in colorectal cancer patients. A longitudinal evaluation. Anticancer Res. Mar-Apr;21(2B):1263-70.

8. Carpelan-Holmström, M., Haglung, K., Lundin, J., Järvinen, H and Roberts, P., (1996) Pre-operative serum levels of CA 242 and CEA predict outcome in colorectal cancer. Eur. J. Cancer 32(7), 1156-1161.

9. Engarås B. (2003 ) Individual cutoff levels of carcinoembryonic antigen and CA 242 indicate recurrence of colorectal cancer with high sensitivity. Dis Colon Rectum. Mar;46(3):313-21.