INNOTEST® NPTX2

INNOTEST NPTX2 is a solid-phase enzyme immunoassay for the quantitative determination of neuronal pentraxin-2 (NPTX2) in human cerebrospinal fluid (CSF).

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INNOTEST® NPTX2

Product number 80908

96 Tests
NPTX2 CAL-RVC pack

Product number 80909

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  • Details

    This assay should be used in combination with the NPTX2 CAL-RVC pack, article no. 80909 (RUO), of the corresponding lot.
     

    Test principle

    The INNOTEST NPTX2 is a solid-phase enzyme immunoassay in which the neuronal pentraxin-2 protein is captured by a first monoclonal antibody, 33F9 (ADx409; IgG1). CSF samples are added and incubated with a biotinylated antibody, 22H10 (ADx410; IgG2a). This antigen-antibody complex is then detected by a peroxidase-labeled streptavidin. After addition of substrate working solution, samples will develop a color. The color intensity is a measure for the amount of human neuronal pentraxin-2 protein in the sample1,2.

    Test principle INNOTEST NPTX2

    Test principle INNOTEST NPTX2 (SV= streptavidin; HRP= horseradish peroxidase).

     
    Background

    Neuronal pentraxin-2 is a synaptic protein that consistently shows decreased CSF concentrations in Alzheimer’s disease compared to control subjects1,2. Preliminary studies indicate that while CSF NPTX2 correlates poorly with the core CSF biomarkers (β-amyloid and tau) and other synaptic markers, it seems to correlate well with cognitive decline2.

     

    References

    1. Jacobs D, et al. A monoclonal antibody based immunoassay for Neuronal Pentraxin2 in CSF. ADPD 2019.
    2. Vanmechelen E, et al. NPTX2 levels in CSF as potential predictor of cognitive dysfunction in the AD continuum. AAIC 2019.

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